Dementia Preventability and Lifestyle Factors
A significant proportion of dementia cases, estimated between 45% and 72%, may be preventable through lifestyle modifications and environmental management. The Lancet Commission attributes 45% of dementia risk to modifiable factors such as hypertension, hearing loss, obesity, physical inactivity, smoking, alcohol consumption, and low levels of early education. Other studies suggest the preventable percentage could be as high as 72% when accounting for additional factors like sleep loss and late-life physical activity. While these statistics represent population-level probabilities rather than individual guarantees, they indicate that individuals can significantly improve their odds of maintaining cognitive health by addressing these variables.
Nutritional Foundations for Brain Health
Proper brain function relies on specific nutrients that support structure and energy metabolism. Omega-3 fatty acids, particularly DHA, are critical for synaptic function and mitochondrial energy production. However, studies indicate that Omega-3 supplementation may only be effective when B-vitamin status (specifically folate, B12, and B6) is adequate, as methylation is required to incorporate DHA into cell membranes.